SUPPORTIVE CARE OF CHILDREN WITH CANCER: PREVENTION AND TREATMENT OF CHEMOTHERAPY-INDUCED LIVER TOXICITY (SPECIFIC MODIFICATIONS OF CHEMOTHERAPEUTIC AGENTS WITH LIVER-DEPENDENT METABOLISM)

A. Vincristine, vinblastine, and VP-16 (etoposide)Bilirubin 3.1 mg/dL or SGOT >180 U/mL: hold dose.B. Adriamycin, daunorubicin, idarubicin, and actinomycin-DBilirubin 180 U/mL: give 25% dose.Bilirubin >5.0 mg/dL: hold dose.C. Methotrexate and cyclophosphamideBilirubin 5.0 mg/dL: hold dose.Restart at 5096 dose when bilirubin 5.0 mg/dL orSGOT >180 U/mL:CCNUBCNU5-FluorouracilCytosine arabinosideDacarbazine (DTIC)Procarbazine*38\168\2*

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This entry was posted on Monday, July 18th, 2011 at 8:46 am and is filed under Cancer. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.

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