Archive for July 18th, 2011

 

SUPPORTIVE CARE OF CHILDREN WITH CANCER: PREVENTION AND TREATMENT OF CHEMOTHERAPY-INDUCED LIVER TOXICITY (SPECIFIC MODIFICATIONS OF CHEMOTHERAPEUTIC AGENTS WITH LIVER-DEPENDENT METABOLISM)

July 18th, 2011

A. Vincristine, vinblastine, and VP-16 (etoposide)Bilirubin <1.5 mg/dL and aspartate aminotransferase (SGOT) <60 U/mL: give 100% dose.Bilirubin 1.5-3.0 mg/dL or SGOT 60-180 U/mL: give 50% dose.Bilirubin >3.1 mg/dL or SGOT >180 U/mL: hold dose.B. Adriamycin, daunorubicin, idarubicin, and actinomycin-DBilirubin <1.5 mg/dL and SGOT <60 U/mL: give 100% dose.Bilirubin 1.5-3.0 mg/dL or SGOT 60-180 U/mL: give [...]

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